Assuntos
Humanos , Tuberculose Latente , Diálise , Transplante de Rim , Diálise Renal , Diálise Peritoneal , Quimioprevenção , Estudos Epidemiológicos , EspanhaRESUMO
No disponible
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Enterococcus/isolamento & purificação , Síndrome de Chilaiditi/complicações , Diálise Peritoneal/efeitos adversos , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/terapia , Peritonite/microbiologia , Antibacterianos/uso terapêuticoRESUMO
No disponible
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Daptomicina/administração & dosagem , Soluções para Hemodiálise/farmacologia , Peritonite/tratamento farmacológico , Diálise Peritoneal/métodos , Diálise Renal/métodosAssuntos
Antibacterianos/administração & dosagem , Infecções Relacionadas a Cateter/tratamento farmacológico , Daptomicina/administração & dosagem , Diálise Peritoneal/efeitos adversos , Peritonite/tratamento farmacológico , Infecções Estafilocócicas/tratamento farmacológico , Staphylococcus epidermidis , Infecções Relacionadas a Cateter/etiologia , Humanos , Infusões Intravenosas , Infusões Parenterais , Masculino , Pessoa de Meia-Idade , Peritonite/etiologia , Recidiva , Infecções Estafilocócicas/etiologia , Staphylococcus epidermidis/efeitos dos fármacos , Staphylococcus epidermidis/isolamento & purificaçãoRESUMO
Introducción: La supervivencia (SV) comparada en terapia renal sustitutiva (TRS) es dependiente de la comorbilidad previa al inicio de TRS y no de la técnica dialítica. Objetivo: Valorar la SV en nuestra población de TRS habida en el periodo 1976-2012 y asimismo la influencia por la transferencia de técnica (TTc). Material y métodos: Cohorte retrospectiva (n = 993 pacientes). Los datos fueron «censurados» por trasplante (TX), cambio de técnica, defunción o pérdida para el seguimiento. La SV por TTc se realizó en pacientes con más de 12 semanas de permanencia. Resultados: El riesgo de mortalidad ajustado por edad, sexo, técnica dialítica o diabetes mellitus (DM) mostró que el riesgo estimado de morir aumenta un 4,8% por cada año aumentado (HR=1,048, IC del 95%, 1,04-1,06, p<0,001) y este aumenta un 44% en los diabéticos con respecto a los no diabéticos (HR=1,44, IC del 95%, 1,16-1,76, p<0,01). En cuanto a la SV por TTc, los que inician HD presentan SV menor que los que inician DP y son transferidos a HD (p=0,00563). Conclusión: En nuestra experiencia, la SV en TRS es dependiente de la edad y la coexistencia de DM y sería conveniente retomar el concepto de «cuidados integrales» comenzado la TRS por DP y transferir a HD(AU)
Objective: To assess SV in our RRT population in the period 1976-2012 as well as the influence of technique transference (TT). Material and methods: The study included a retrospective cohort of 993 patients. Data were classified as transplant (Tx), change in technique, exitus or lost to follow-up. SV for TT was determined in patients with over 12 weeks of permanence. Results: The mortality risk adjusted for age, sex, dialysis technique or diabetes mellitus (DM) showed that the estimated risk of death increased by 4.8% per year increase (HR=1.048; 95% CI: 1.04-1.06; P<.001) and was 44% higher in diabetics compared to non-diabetics (HR=1.44; 95% CI 1.16-1.76; P<.01). Regarding SV for TT, patients who initiated HD had a shorter survival than those who initiated PD and transferred to HD(P=.00563). Conclusion: In our experience, SV in RRT is dependent on age and coexistence of DM. It would be beneficial to reinstate the concept of 'comprehensive care', in which RRT would start with PD and later transfer to HD (AU)
Assuntos
Humanos , Diálise Renal/estatística & dados numéricos , Diálise Peritoneal/estatística & dados numéricos , Insuficiência Renal Crônica/terapia , Análise de Sobrevida , Terapia de Substituição Renal/estatística & dados numéricosRESUMO
OBJECTIVE: To assess SV in our RRT population in the period 1976-2012 as well as the influence of technique transference (TT). MATERIAL AND METHODS: The study included a retrospective cohort of 993 patients. Data were classified as transplant (Tx), change in technique, exitus or lost to follow-up. SV for TT was determined in patients with over 12 weeks of permanence. RESULTS: The mortality risk adjusted for age, sex, dialysis technique or diabetes mellitus (DM) showed that the estimated risk of death increased by 4.8% per year increase (HR=1.048; 95% CI: 1.04-1.06; P<.001) and was 44% higher in diabetics compared to non-diabetics (HR=1.44; 95% CI 1.16-1.76; P<.01). Regarding SV for TT, patients who initiated HD had a shorter survival than those who initiated PD and transferred to HD (P=.00563). CONCLUSION: In our experience, SV in RRT is dependent on age and coexistence of DM. It would be beneficial to reinstate the concept of "comprehensive care", in which RRT would start with PD and later transfer to HD.
Assuntos
Diálise Peritoneal/mortalidade , Diálise Renal/mortalidade , Transferência de Tecnologia , Uremia/mortalidade , Adulto , Fatores Etários , Idoso , Assistência Integral à Saúde , Nefropatias Diabéticas/mortalidade , Nefropatias Diabéticas/terapia , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Risco , Fatores Sexuais , Espanha/epidemiologia , Uremia/terapiaRESUMO
BACKGROUND: Peritoneal dialysis (PD) is a form of renal replacement used for advanced chronic kidney disease. PD effluent holds a great potential for biomarker discovery for diagnosis and prognosis. In this study a novel approach to unravelling the proteome of PD effluent based-on dithiothreitol depletion followed by 2D-SDS-PAGE and protein identification using tandem mass spectrometry is proposed. RESULTS: A total of 49 spots were analysed revealing 25 proteins differentially expressed, among them many proteins involved in calcium regulation. CONCLUSIONS: Remarkably, a group of proteins dealing with calcium metabolism and calcium regulation has been found to be lost through peritoneal dialysate effluent, giving thus a potential explanation to the calcification of soft tissues in patients subjected to peritoneal dialysis and kidney injury. Comparison of literature dealing with PD is difficult due to differences in sample treatment and analytical methodologies.
